(Isithiyo sobuchopho, BBB)
Umgoqo wegazi nobuchopho ungenye yezindlela ezibalulekile zokuzivikela kubantu.Yakhiwa amangqamuzana e-capillary endothelial yobuchopho, amaseli e-glial, ne-choroid plexus, evumela kuphela izinhlobo ezithile zama-molecule asuka egazini ukuthi zingene kuma-neurons obuchopho namanye amangqamuzana azungezile, futhi zingavimbela izinto ezihlukahlukene eziyingozi ukuthi zingangeni ezicutshini zobuchopho.Ubuchopho, njengengxenye eyimfihlo nebalulekile yomzimba womuntu, bulawula imisebenzi eminingi ebalulekile.Umgoqo wegazi nobuchopho ungavimba izinto eziyingozi egazini futhi uvikele ukuphepha kwezicubu zobuchopho.
Isifo i-Alzheimer's, AD
Isifo i-Alzheimer's (AD) yisifo se-neurodegenerative esiqhubekayo esiqala ngobuqili.Emisebenzini yomtholampilo, ukuwohloka komqondo okuphelele kubonakala ngokukhubazeka kwenkumbulo, i-aphasia, i-aphasia, ukulahlekelwa ukuqashelwa, ukonakala kwamakhono okubukwayo nendawo, ukungasebenzi kahle kwe-executive, kanye nezinguquko zobuntu kanye nokuziphatha.I-etiology namanje ayaziwa.Ukuwohloka komqondo ngaphambi kwesikhathi kubhekisela kubantu ababa nezimpawu ngaphambi kweminyaka yobudala engama-65;Abantu abaqala ukuwohloka komqondo ngemva kweminyaka yobudala engama-65 babizwa ngokuthi ukuwohloka komqondo ongasenangqondo.Ukwenzeka kwesifo i-Alzheimer's (AD) kuvame ukuhlotshaniswa ne-β- Amyloid protein (A β） Ukunqwabelana kanye ne-Tau protein entanglement kuyaxhunyaniswa, futhi ucwaningo olwengeziwe lubeka kancane kancane uhlu lwe-neuroinflammation njengesinye sezici ezinomthelela ekuveleni kwe-AD.
I-Quote: Siyini isifo i-Alzheimer's?Bheka lolu lwazi.I-People's Daily Online.2023-09-20
Qaphela ukuthi kunohlobo lwebhaktheriya olungangena kumgoqo wegazi nobuchopho
Muva nje, abacwaningi abavela e-Baylor College of Medicine e-United States bashicilele iphepha locwaningo elinesihloko esithi: I-Toll like receptor 4 ne-CD11b evezwe ekusulweni kwe-microglia ye-Candida albicans cerebral mycosis kujenali ye-Cell Reports.
Sithole ukhunta okuthiwa i-Candida albicans olungangena ebuchosheni ngokusebenzisa igazi.Njengoba isisho esidumile sisho, “Ukukhahlela umlenze womuntu okhubazekile kungabangela isifo se-Alzheimer njengoshintsho.”Kulolu cwaningo, siphinde saveza izindlela zamangqamuzana i-Candida albicans egqekeza ngayo umgoqo wegazi nobuchopho futhi ingene ebuchosheni, okuholela esifweni se-Alzheimer njengezinguquko.
Ngabe i-Candida albicans ingena kanjani ebuchosheni?“Sithole ukuthi i-Candida albicans ikhiqiza i-enzyme ebizwa ngokuthi i-secreted aspartate protease (Saps), ephazamisa umgoqo wegazi nobuchopho, ivumele isikhunta singene ebuchosheni bese sidala umonakalo,” kusho uDkt. Yifan Wu, usosayensi wezingane osebenza eCorry. Ilabhorethri.
Candida albicans
I-Candida albicans (igama lesayensi: Candida albicans) imvubelo engabangela izifo ezingosomathuba.Ivame ukutholakala emphakathini webhaktheriya wokugaya ukudla komuntu kanye namapheshana e-urogenital.Cishe u-40% kuya ku-60% wabantu abadala abanempilo enhle banama-Candida albicans emapheshaneni abo omlomo nowokugaya ukudla.I-Candida albicans ivame ukuhlala ndawonye nomzimba womuntu, kodwa ingakhula ngesikhathi sokuntuleka kwamasosha omzimba futhi ibangele i-candidiasis.Yigciwane elivame kakhulu le-pathogenic kuhlobo lwe-Candida
Ngokocwaningo lwe-Cell Reports, isikhunta esivame ukunganaki kakhulu singase sibe esinye sezimbangela zesifo i-Alzheimer's.Abacwaningi abavela e-Baylor School of Medicine kanye nezikhungo ezisebenzisanayo bathole ngezibonelo zezilwane ukuthi i-Candida albicans ingena kanjani ebuchosheni nokuthi ivula kanjani izindlela ezimbili ezizimele kumangqamuzana obuchopho akhuthaza ukucaciswa kwayo (okubalulekile ekuqondeni ukuthuthukiswa kwesifo i-Alzheimer's), futhi bakhiqize. I-β Amyloid protein (A β） Peptides (izingcezu zamaprotheni anobuthi ze-amyloid protein) zithathwa njengomongo wokukhula kwesifo i-Alzheimer's.
UDkt David Corry uthe.UDavid Corry unguSihlalo we-Pathology eFulbright Foundation kanye noprofesa wezifo, i-immunology, kanye nemithi e-Baylor University.Uphinde abe yilungu le-Baylor L. Duncan Comprehensive Cancer Centre.Ngo-2019, sithole ukuthi ama-Candida albicans angena ngempela ebuchosheni futhi akhiqiza izinguquko ezifana ncamashi nesifo i-Alzheimer's.Ukuvuvukala okubangelwa ama-Candida albicans kuvame ukuhambisana
A β Isizathu sokukhiqizwa kwe-amyloid efana nama-peptide ukuthi i-Sap ingakwazi uku-hydrolyze ama-amyloid precursor proteins (APPs).
Kodwa-ke, lawa ma-peptide aphinde adonse ukunaka kwamangqamuzana omzimba obuchopho - i-microglia, ebalulekile ekususweni okulandelayo kwe-Candida albicans ngubuchopho uqobo.Ngaphezu kwalokho, ubuthi i-Candidalysin obukhiqizwa ama-Candida albicans buvuselela i-microglia ngenye indlela.Uma le ndlela iphazamiseka, isikhunta ebuchosheni asikwazi ukuqedwa.
Abacwaningi baveza ukuthi lo msebenzi ungase ube indida ebalulekile ekuqondeni ukwenzeka kwesifo i-Alzheimer's.Ucwaningo lwangaphambilini luphakamise ukuthi ama-proteases ebuchosheni abambe iqhaza ekuhlukaniseni izinhlelo zokusebenza futhi anikele ku-A β Ukuqoqwa kwesisekelo.Futhi manje kungaqinisekiswa ukuthi le protease yangaphandle evela kusikhunta nayo ingabangela ukukhiqizwa kwe-A β Peptide.
Abacwaningi baveza ukuthi ukuhlolwa okwengeziwe kwendima ye-Candida albicans ekuthuthukisweni kwesifo i-Alzheimer kuyadingeka esikhathini esizayo, okungase kuholele kumasu amasha okwelapha e-AD.
Izinto eziyisethenjwa:
[1] U-Yifan Wu et al, I-Toll like receiver 4 ne-CD11b evezwe ku-microglia ihlanganisa ukusulwa kwe-Candida albicans cerebral mycosis, Imibiko Yeseli (2023) DOI: 10.1016/j.celrep.2023.113240
[2] Imikhiqizo yokutheleleka kobuchopho obusebenzayo Isifo i-Alzheimer's njengezinguquko, kusho ucwaningo olusha Itholwe ngomhlaka-17 Okthoba, 2023 kusukela ku-https://medicalxpress.com/news/2023-10-brain-fungal-infection-alzheimer-disease-like.html
Isikhathi sokuthumela: Dec-22-2023